The %Biotech field is no stranger to scientific breakthroughs, but combining novel therapeutic platforms with progressive treasury strategies is relatively new, and potentially disruptive. Many companies, including early-stage biotech companies, are searching for ways to capitalize on Ethereum (or other cryptocurrencies) as part of next-gen sustainable funding models. In the case of biotech, some are early adopters pairing drug pipelines with digital asset exposure to strengthen their balance sheets and reduce dependence on traditional financing.
To see the ETH/BTC strategy in effect, it helps to examine a few companies implementing bold moves to build investor value.
%ETHZilla (Nasdaq: $ETHZ) recently raised around $425 million via a private placement, and an additional $156 million via convertible notes to fuel its %Ethereum (CRYPTO: $ETH) treasury strategy. A biotech not long ago known as 180 Life Sciences (seeking to monetize its legacy biotech assets), ETHZ is now a technology company in the decentralized finance industry seeking to connect financial institutions, businesses and organizations worldwide by enabling secure, accessible blockchain transactions through Ethereum Network protocol implementations. It generates recurring revenues through various decentralized finance ("DeFi") protocols that improve Ethereum network integrity and security.
BTCS, Inc. (Nasdaq: $BTCS) has been steadily increasing its holdings of Ethereum as part of its long-term digital asset accumulation strategy. For instance, it recently acquired 3,450 ETH (approximately $8.42 million in one transaction), viewing the asset as foundational to its operations and strategy. The company has positioned itself as a pioneer in blockchain infrastructure and digital asset management, consistently demonstrating its commitment to Ethereum as a primary treasury reserve asset while exploring additional revenue opportunities through staking and validation services.
%QuantumBioPharma Ltd. (CSE: QNTM) (Nasdaq: $QNTM) is taking a smaller-scale but still relevant approach by expanding its %Cryptocurrency holdings (Bitcoin and other cryptos) to approximate CDN$4.5 million, and planning to stake part of those assets to generate returns and hedge against local currency and macro risk. This Canadian life sciences company has integrated crypto treasury management alongside its pharmaceutical development programs, providing a model for how smaller biotech firms can adopt digital asset strategies proportionate to their size while maintaining focus on their core therapeutic missions.
These comparables illustrate different scales and emphases: from large ETH treasury builds (ETHZilla) to more modest but strategic crypto allocations (Quantum BioPharma).
One of the most interesting cases in this evolving intersection is Propanc Biopharma, Inc. (Nasdaq: PPCB). Propanc is following a somewhat analogous course, but with its own distinct blend of science and finance. Its therapeutic mission is focused on preventing recurrence and metastasis in solid tumors by using pancreatic proenzymes that specifically target cancer stem cells in diseases such as pancreatic, ovarian, and colorectal cancer.
On September 2, 2025, Propanc announced its plan to acquire $100 million of Ethereum over the next 12 months, as part of a multi-faceted strategy combining cryptocurrency exposure, pharmaceutical drug development, and asset acquisition. The goal is to supplement traditional financing, create optionality via asset diversification, address cash flow needs during pre-revenue stages, accelerate commercialization of its IP assets, and explore opportunities to expand its intellectual property portfolio through acquisitions.
%Propanc argues that Ethereum has several advantages over %Bitcoin (CRYPTO: $BTC): smart contract support, decentralized apps (DApps), tokenization possibilities for real-world assets (RWAs), and Ethereum's transition to a proof-of-stake consensus mechanism, which may offer efficiency and sustainability improvements. These features are central to the company's rationale for selecting ETH as its core crypto exposure. CEO James Nathanielsz has stated that "tokenization on Ethereum offers significant advantages, including enhanced liquidity for traditionally illiquid assets, global accessibility through fractional ownership, increased security and transparency via its blockchain, and greater cost and transaction efficiency."
The company's therapeutic platform, PRP (pancreatic proenzyme therapy), represents a fundamentally different approach to %Cancer treatment. Rather than destroying cancer cells through traditional cytotoxic mechanisms, PRP works by reprogramming malignant and cancer stem cells, interrupting tumor proliferation and metastasis through cellular differentiation. This mechanism addresses epithelial-to-mesenchymal transition (EMT), a critical biological process that enables cancer cells to become mobile invaders capable of spreading throughout the body.
PRP is a mixture of two proenzymes (trypsinogen and chymotrypsinogen from bovine pancreas) administered by intravenous injection. A synergistic ratio of 1:6 inhibits growth of most tumor cells, including pancreatic, ovarian, kidney, breast, brain, prostate, colorectal, lung, liver, uterine, and skin cancers. The therapy acts as an "EMT modulator" that reprograms cancer cells so they are no longer malignant and die naturally, potentially free from the severe or serious side effects associated with standard treatments.
On the IP front, Propanc holds 90 patents across key jurisdictions for its PRP therapy, covering not just the composition but also methods for its proposed clinical dose, EMT modulation, and cancer stem cell targeting. The company recently secured a U.S. grant for its "clinical dose" patent, which should help protect the formulation it intends to use in human trials. This intellectual property fortress ensures that no competitors can replicate the approach without licensing, creating a comprehensive moat around the technology.
The dual strategy is designed to do more than hedge risk: It is intended to stretch resources, reduce dependency on equity dilution, and provide potential upside if ETH appreciates or if tokenization of assets or revenue becomes viable. Since listing on the Nasdaq on August 15, 2025, Propanc has been executing this strategic corporate action, utilizing its corporate structure as a Delaware parent company with a wholly owned Australian subsidiary to create flexibility for commercializing and potentially spinning off key IP assets in the future.
Propanc's positioning reflects broader industry trends where the lines between traditional biotech financing and digital asset strategies continue to blur. The company aims to submit a clinical trial application for its Phase 1, first-in-human study by the first half of 2026 at the Peter MacCallum Cancer Centre in Melbourne, Australia, a leading cancer hospital consistently ranking among the top 20 %Oncology centers globally.
Investors should monitor several upcoming catalysts: (1) timing and pace of the planned $100 million ETH acquisitions; (2) early clinical data from PRP as the company advances toward Phase 1 trials; (3) new patents or regulatory designations that further strengthen IP protection; (4) partnerships or licensing deals that may validate the PRP biology and attract Big Pharma interest; and (5) how well Propanc's treasury strategy is executed, including transparency around custody, potential staking or yield generation, and overall risk management of its digital asset holdings.
The convergence of breakthrough cancer science with innovative treasury management represents a new frontier in biotech financing. For Propanc, the combination of 90-patent IP protection, a novel therapeutic mechanism targeting cancer stem cells and EMT, and a bold Ethereum acquisition strategy creates a unique value proposition that extends beyond traditional biotech investment theses. Whether this model proves successful could have implications far beyond a single company, potentially reshaping how early-stage biotechs fund their journey from discovery to commercialization.
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